▶ 일시 : 2023년 9월 5일(화) 10:30 ~ 12:00

▶ 장소 : 연세대학교 과학관 B101호

▶ 대상 : 신경과학에 관심 있는 교수 및 학생 모두

▷ 연사: Garrett B. Stanley, Georgia Institute of Technology and Emory University, USA

▷ 제목 : Windows of opportunity in the thalamocortical circuit 2.0: a canonical computation? 

▷ 주제:  in vivo and computational approaches to understand sensory signaling

▷ 문의 : 정은지 교수 (내선 : 5885)

Title : Windows of opportunity in the thalamocortical circuit 2.0: a canonical computation?

Garrett B. Stanley, Professor

Coulter Department of Biomedical Engineering

Georgia Institute of Technology and Emory University, USA

Abstract:

The sensory thalamus has long been described as a “gate” of sensory signaling from periphery to cortex. Underlying this gating is a range of intrinsic biophysical properties of the thalamic neurons themselves, but also importantly the way in which the thalamic neurons project and synapse onto their cortical targets. Disynaptic inhibition at the thalamocortical (TC) junction is a particularly prominent motif that is thought to play a major role in regulating signaling through sensitivity to timing and synchrony of thalamic inputs to cortex, establishing what is often referred to as a “window of opportunity” for sensory signaling. This mechanism is ubiquitous in the thalamocortical circuit and is a computational mechanism that subserves feature selectivity and shapes perception. In this talk, I will briefly describe the relevant anatomy, describe intracellular studies that have captured the nature of the excitatory/inhibitory interaction, and describe functional studies that illustrate how this shapes selectivity and controls information flow in sensory pathways.

Keywords:

Thalamocortical, Synchrony, Selectivity, Signaling